Most Recent/Major Publications

 

Publications list : 

revApplications of ion mobility mass spectrometry for high throughput, high resolution glycan analysis, C.J. Gray , B. Thomas , R. Upton , L.G. Migas , C.E. Eyers , P.E. Barran , S.L. Flitsch | http://dx.doi.org/10.1016/j.bbagen.2016.02.003 | Biochimica et Biophysica Acta (BBA) – General Subjects Available online 6 February 2016

 

 

ToC figureMolecular Insights into the Thermal Stability of mAbs with Variable-Temperature Ion-Mobility Mass Spectrometry, Kamila J. Pacholarz, Shirley J. Peters, Rachel A. Garlish, Alistair J. Henry, Richard J. Taylor,  David P. Humphreys and Perdita E. Barran | DOI: 10.1002/cbic.201500574 | ChemBioChem, 2016, 17, 46-51.

 

 

248In Vitro–In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part II. The Impact of Cross-Laboratory Variations of Intestinal Transporter Relative Expression Factors on Predicted Drug Disposition,  Matthew D. Harwood, Brahim Achour, Sibylle Neuhoff, Matthew R. Russell, Gordon Carlson, Geoffrey Warhurst, and Amin Rostami-Hodjegan | http://dx.doi.org/10.1124/dmd.115.067777 | February 3, 2016, DMD  vol. 44 no. 3 476-480

 

297In Vitro–In Vivo Extrapolation Scaling Factors for Intestinal P-Glycoprotein and Breast Cancer Resistance Protein: Part I: A Cross-Laboratory Comparison of Transporter-Protein Abundances and Relative Expression Factors in Human Intestine and Caco-2 Cells, Matthew D. Harwood, Brahim Achour, Sibylle Neuhoff, Matthew R. Russell, Gordon Carlson, Geoffrey Warhurst, and Amin Rostami-Hodjegan | dx.doi.org/10.1124/dmd.115.067371 | December 2, 2015, DMD March 2016 vol. 44 no. 3 297-307

 

1-s2.0-S1387380615002523-fx1Ten years of QconCATs: Application of multiplexed quantification to small medically relevant proteomes, Brahim Achour, Zubida M. Al-Majdoub, Hajar Al Feteisi, Yasmine Elmorsi, Amin Rostami-Hodjegan, Jill Barber | doi:10.1016/j.ijms.2015.08.003 | International Journal of Mass Spectrometry, Volume 391, 30 November 2015, Pages 93–104, SI:Simon Gaskell honor issue

 

 

ncomms8907-f1The photochemical mechanism of a B12-dependent photoreceptor protein,  Roger J. Kutta, Samantha J.O. Hardman, Linus O. Johannissen, Bruno Bellina, Hanan L. Messiha, Juan Manuel Ortiz-Guerrero, Montserrat Elı´as-Arnanz, S. Padmanabhan, Perdita Barran, Nigel S. Scrutton & Alex R. Jones | doi:10.1038/ncomms8907 | Nature Communications 6,Article number:7907

 

 

ellie1_pap1The use of ion mobility mass spectrometry to probe modulation of the structure of p53 and of MDM2 by small molecule inhibitors,  Eleanor R. Dickinson, Ewa Jurneczko, Judith Nicholson, Ted R. Hupp, Joanna Zawacka-Pankau, Galina Selivanova, and Perdita E. Barran. Front Mol Biosci. 2015; 2: 39. doi:  10.3389/fmolb.2015.00039

 

 

kam1_pap1_2

Distinguishing Loss of Structure from Subunit Dissociation for Protein Complexes with Variable Temperature Ion Mobility Mass Spectrometry, Kamila J. Pacholarz and Perdita E. Barran ; Anal. Chem., 2015, 87 (12), pp 6271–6279   DOI: 10.1021/acs.analchem.5b01063

 

 

synapt_analystUV photodissociation of trapped ions following ion mobility separation in a Q-ToF mass spectrometer, Bruno Bellina, Jeffery. M. Brown, Jakub Ujma, Paul Murray, Kevin Giles, Michael Morris, Isabelle Compagnon and Perdita. E. Barran ;  Analyst, 2014,139, 6348-6351     DOI: 10.1039/C4AN01656D

 

 

1Discrimination of epimeric glycans and glycopeptides using IM-MS and its potential for carbohydrate sequencing, Both, A. P. Green, C. J. Gray, R. Šardzík, J. Voglmeir, C. Fontana, M. Austeri, M. Rejzek,D. Richardson, R. A. Field, G. Widmalm, S. L. Flitsch & C. E. Eyers ; Nature Chemistry6,65–74doi:10.1038/nchem.1817

 

 

2Enzymatic reactions on immobilised substrates, Christopher J. Gray,  Martin J. Weissenborn, Claire E. Eyers and  Sabine L. Flitsch ; Chem. Soc. Rev., 2013,42, 6378-6405    DOI: 10.1039/C3CS60018A