Publications

– 2013 – 2012 – 2011 – 2010 – 2009 – 2008 – 2007 – 2006 – 2005 – <2004 – Chapters

2014 | Back to top |

71. Unusual ECD fragmentation attributed to gas-phase helix formation in a conformationally dynamic peptide
Jason MD Kalapothakis, Yana Berezovskaya, Cleidiane G Zampronio, Peter A Faull, Perdita E Barran, Helen J Cooper Chemical Communications , 2014, 50, 2, 198-200.

2013 | Back to top |

70. Partial deletion of chromosome 8 β-defensin cluster confers sperm dysfunction and infertility in male mice
Yu S Zhou, Sheila Webb, Laura Lettice, Steve Tardif, Fiona Kilanowski, Christine Tyrrell, Heather MacPherson, Fiona Semple, Peter Tennant, Tina Baker, Alan Hart, Paul Devenney, Paul Perry, Tracey Davey, Perdita Barran, Chris L Barratt, Julia R Dorin PLOS Genetics , 2013, 9, 10.

69. Probing the Conformational Diversity of Cancer‐Associated Mutations in p53 with Ion‐Mobility Mass Spectrometry
Jurneczko E., Cruickshank F., Porrini M., Clarke D.J., Campuzano I.D.G., Morris M., Nikolova P.V., Barran P.E. Angewandte Chemie International Edition, 2013, 125, 16, 4466-4470

68. The effect of salt on the conformations of three model proteins is revealed by variable temperature ion mobility mass spectrometry
Berezovskaya Y., Porrini M., Barran P.E. International Journal of Mass Spectrometry, 2013, 345, 8-18

67. Effect of Protonation State on the Stability of Amyloid Oligomers Assembled from TTR (105–115)
Massimiliano Porrini, Ulrich Zachariae, Perdita E Barran, Cait E MacPhee The Journal of Physical Chemistry Letters, 2013, 8, 1233-1238

66. Structural studies of metal ligand complexes by ion mobility-mass spectrometry
Wright V.E., Castro-Gómez F., Jurneczko E., Reynolds J.C.., Poulton A., Christie S.D.R., Barran P.E., Bo C., Creaser C.S. International Journal of Ion Mobility Spectrometry, 2013, 16, 61-67

65. Ion Mobility Mass Spectrometry–Principles
Jason MD Kalapothakis, Perdita E Barran Encyclopedia of Biophysics, 2013, 1142-1148

64. Mass Spectrometry Methods for Intrinsically Disordered Proteins.
Beveridge, R., Chappuis, Q., MacPhee, C., Barran, P.E. Analyst, 2013, 138, 32-42.

2012 | Back to top |

63. Small-molecule inhibition of c-MYC:MAX leucine zipper formation is revealed by ion mobility mass spectrometry.
Harvey, S. R., Porrini, M., Stachl, C., MacMillan, D., Zinzalla, G., Barran, P.E. J. Am. Chem. Soc., 2012, 134, 19384–19392

62. Luminescent, Enantiopure, Phenylatopyridine Iridium-Based Coordination Capsules.
Chepelin, O., Ujma, J., Wu, X., Slawin, A.M.Z., Pitak, M. B., Coles, S. J., Michel, J., Jones, A. C., Barran, P. E., Lusby, P. J. J. Am. Chem. Soc., 2012, 134, 19334–19337

61. QconCAT Standard for Calibration of Ion Mobility- Mass Spectrometry Systems.
Chawner, R., McCullough, B., Giles, K., Barran, P.E., Gaskell, S. J., Eyers, C. E. J. Proteome Res., 2012, 11, 5564–5572

60. Effects of Drift Gas on Collision Cross Sections of a Protein Standard in Linear Drift Tube and Travelling Wave Ion Mobility Mass Spectrometry
Jurneczko, E., Kalapothakis, J.M.D., Campuzano, I.D.G., Morris, M., Barran, P.E. Anal. Chem., 2012, 84, 8524–8531

59. Intrinsic disorder in proteins: a challenge for (un)structural biology met by ion mobility-mass spectrometry.
Jurneczko, E., Cruickshank, F., Porrini, M., Nikolova, P., Campuzano, I.D.G., Morris, M., Barran, P.E. Biochem. Soc. Trans. 2012, 40, 1021-U372.

58. Mass spectrometry based tools to investigate protein-ligand interactions for drug discovery. Pacholarz, K.J., Garlish, R.A., Taylor, R.J. & Barran, P.E. Chem. Soc. Rev. 2012, 41, 4335-4355.

57. Shapes of supramolecular cages by ion mobility mass spectrometry.
Ujma, J., De Cecco, M., Chepelin, O., Levene, H., Moffat, C., Pike, S.J., Lusby, P.J., and Barran, P.E. Chem. Comm. 2012, 48, 4423-4425.

56. Sequential, Kinetically Controlled Synthesis of Multicomponent Stereoisomeric Assemblies. Chepelin, O., Ujma, J., Barran, P.E., and Lusby, P.J. Angew Chem-Int Edit,2012, 51, 4194-4197.

55. Identification and proteomic profiling of exosomes in human cerebrospinal fluid.
Street, J.M., Barran, P.E., Mackay, C.L., Weidt, S., Balmforth, C., Walsh, T.S., Chalmers, R.T.A., Webb, D.J., and Dear, J.W. J Transl Med. 2012, 10, 5.

2011 | Back to top |

54. Active-Metal Template Synthesis of a Molecular Trefoil Knot.
Barran, P.E., Cole, H.L., Goldup, S.M., Leigh, D.A., McGonigal, P.R., Symes, M.D., Wu, J.Y., and Zengerle, M., Angew Chem-Int Edit, 2011,50, 12280-12284.

53. Synthesis of Cyclic Peptides through an Intramolecular Amide Bond Rearrangement.
Macmillan, D., De Cecco, M., Reynolds, N.L., Santos, L.F.A., Barran, P.E., and Dorin, J.R., ChemBioChem, 2011,12, 2133-2136.

52. Evidence for alpha-helices in the gas phase: A case study using Melittin from honey bee venom.
Florance, H.V., Stopford, A.P., Kalapothakis, J.M., McCullough, B.J., Bretherick, A., and Barran, P.E. Analyst, 2011,136, 3446-3452.

51. Ion mobility mass spectrometry for peptide analysis.
Harvey, S.R., MacPhee, C.E., and Barran, P.E. , Methods, 2011, 54, 454-461.

50. (Re)Solution of a Protein Fold Without Solution.
Barran, P.E., Angew Chem-Int Edit, 2011, 50, 3120-3122.

49. Design and Synthesis of Conformationally Constrained Cyclophilin Inhibitors Showing a Cyclosporin-A Phenotype in C. elegans.
Dunsmore, C.J., Malone, K.J., Bailey, K.R., Wear, M.A., Florance, H., Shirran, S., Barran, P.E., Page, A.P., Walkinshaw, M.D., and Turner, N.J., ChemBioChem, 2011,12, 802-810.

48. Metal binding to a zinc-finger peptide: a comparison between solution and the gas phase. Berezovskaya, Y., Armstrong, C.T., Boyle, A.L., Porrini, M., Woolfson, D.N., and Barran, P.E. , Chem. Comm.,2011, 47, 412-414.

47. How useful is ion mobility mass spectrometry for structural biology? The relationship between protein crystal structures and their collision cross sections in the gas phase.
Jurneczko, E., and Barran, P.E., The Analyst, 2011, 136, 20-28.

2010 | Back to top |

46. Interaction of Human beta-Defensin 2 (HBD2) with Glycosaminoglycans. Seo, E.S., Blaum, B.S., Vargues, T., De Cecco, M., Deakin, J.A., Lyon, M., Barran, P.E., Campopiano, D.J., and Uhrin, D., Biochem., 2010, 49, 10486-10495.

45. Characterizing Early Aggregates Formed by an Amyloidogenic Peptide by Mass Spectrometry. Cole, H.L., Kalapothakis, J.M.D., Bennett, G., Barran, P.E., and MacPhee, C.E. , Angewandte Chemie, 2010,122, 9638-9641.

44. Utilising ion mobility-mass spectrometry to interrogate macromolecules: Factor H complement control protein modules 10–15 and 19–20 and the DNA-binding core domain of tumour suppressor p53.
Faull, P.A., Florance, H.V., Schmidt, C.Q., Tomczyk, N., Barlow, P.N., Hupp, T.R., Nikolova, P.V., and Barran, P.E., Int. J. Mass Spectrom., 2010,298, 99-110.

43. Selective Chemical Intervention in the Proteome of Caenorhabditis elegans.
Husi, H., McAllister, F., Angelopoulos, N., Butler, V.J., Bailey, K.R., Malone, K., MacKay, L., Taylor, P., Page, A.P., Turner, N.J., Barran, P. E. and Walkinshaw, M. , J. Proteome res., 2010,9, 6060-6070.

42. A comparison of mass spectrometry based hydrogen deuterium exchange methods for probing the cyclophilin A cyclosporin complex.
Esswein, S.T., Florance, H.V., Baillie, L., Lippens, J., and Barran, P.E., J. Chromatogr. A.,2010, 1217, 6709-6717.

41. Peptide Fragments of a -Defensin Derivative with Potent Bactericidal Activity.
Reynolds, N.L., De Cecco, M., Taylor, K., Stanton, C., Kilanowski, F., Kalapothakis, J., Seo, E., Uhrin, D., Campopiano, D., Govan, J.,Macmillan, D, Barran, P. E., Dorin, J. R., Antimicrob. Agents Chemother., 2010,54, 1922-1929.

40. Binding a heparin dervied disaccharide to defensin inspired peptides Inisights to antimicobial inhibition from gas-phase measurements.
McCullough, B., Kalapothakis, J., Wutharath, C., Taylor, K., Clarke, D.J., Eastwood, H., Campopiano, D., MacMillan, D., Dorin, J.R., and Barran, P. , Phys. Chem. Chem. Phys., 2010 , 12, 3589-3596.

39. Isoleucine/leucine2 is essential for chemoattractant activity of β-defensin Defb14 through chemokine receptor 6.
Tyrrell, C., De Cecco, M., Reynolds, N.L., Kilanowski, F., Campopiano, D., Barran, P., Macmillan, D., and Dorin, J.R., Molecular Immunology, 2010,47, 1378-1382.

38. Conformational preferences of linear B-defensins are revealed by Ion Mobility-Mass Spectrometry.
De Cecco, M., Seo, E., Clark, D.J., McCullough, B., Taylor, K., MacMillan, D., Dorin, J.R., Campopiano, D., and Barran, P., J. Phys. Chem. B, 2010,114, 2312-2318.

2009 | Back to top |

37. Gas-phase metalloprotein complexes interrogated by ion mobility-mass spectrometry.
Faull, P.A., Korkeila, K.E., Kalapothakis, J.M., Gray, A., McCullough, B.J., and Barran, P.E., Int. J. Mass Spectrom., 2009, 283, 140-148.

36. Proteomic investigation of human urinary microparticles.
Street, J.; Barran, P.; McAllister, F.; Webb, D.; Dear, J., Br. J. Clin. Pharm., 2009, 68, 284-285.

35. Cyclophilin A is a novel mediator of paracetamol-induced liver injury.
Dear, J.; Huizinga, T.; Nicolai, M.; Barran, P.; Walkinshaw, M.; Simpson, K.; Bateman, D. N.; Waring, W. S.; Webb, D. J., ., Br. J. Clin. Pharm., 2009, 68, 277-278.

34. The Use of ESI-MS to Probe the Binding of Divalent Cations to Calmodulin.
Shirran, S.L., and Barran, P.E. , J. Am. Soc. Mass Spectrom., 2009,20, 1159-1171

33. Defensin-related peptide 1 (Defr1) is allelic to Defb8 and chemoattracts immature DC and CD4(+) T cells independently of CCR6.
Taylor, K., Rolfe, M., Reynolds, N., Kilanowski, F., Pathania, U., Clarke, D., Yang, D., Oppenheim, J., Samuel, K., Howie, S., Barran, P. E., Macmillan, D, Campopiano, D and Dorin, J., Eur J Immunol, 2009,39, 1353-1360.

2008 | Back to top |

32. Development of an Ion Mobility Quadrupole Time of Flight Mass Spectrometer.
McCullough, B.J., Kalapothakis, J., Eastwood, H., Kemper, P., MacMillan, D., Taylor, K., Dorin, J., and Barran, P.E., Anal. Chem., 2008,80, 6336-6344.

31. Analysis and Separation of Residues Important for the Chemoattractant and Antimicrobial Activities of -Defensin 3.
Taylor, K., Clarke, D. J., Mccullough, B., Chin, W., Seo, E., Yang, D., Oppenheim, J., Uhrin, D., Govan, J. R. W., Campopiano, D. J., MacMillan, D., Barran, P., Dorin, J. R., J. Bio. Chem., 2008,283, 6631-6639.

30. Review: Structure-activity relationships in beta-defensin peptides .
Taylor, K., Barran, P.E., and Dorin, J.R., Biopolymers., 2008, 90, 1-7.

29.. Urinary microparticles are a source of protein for biomarker discovery in sepsis.
Street, J.; Kara, M.; McAllister, F.; Johnston, S.; Webb, D.; Barran, P.; Dear, J., Br. J. Clin. Pharm., 2008, 65, 992-993.

2007 | Back to top |

28. Covalent Dimer Species of -Defensin Defr1 Display Potent Antimicrobial Activity against Multidrug-Resistant Bacterial Pathogens
Taylor, K., McCullough, B., Clarke, D. J., Langley, R. J., Pechenick, T., Hill, A., Campopiano, D. J., Barran, P.E., Dorin, J. R. and Govan, J. R. W., Antimicrob. Agents Chemother., 2007, 51, 1719-1724.

27. GnRH-mediated DAN production regulates the transcription of the GnRH receptor in gonadotrope cells.
De Maturana, R.L., Martin, B., Millar, R.P., Brown, P., Davidson, L., Pawson, A.J., Nicol, M.R., Mason, J.I., Barran, P., Naor, Z., and Maudsley, S., Neuromol Med, 2007,9, 230-248.

2006 | Back to top |

26. Characterisation of DEFB107 by mass spectrometry: Lessons from an anti-antimicrobial defensin McCullough, B.J., Eastwood, H., Clark, D.J., Polfer, N.C., Campopiano, D.J., Dorin, J.A., Maxwell, A., Langley, R.J., Govan, J.R.W., and Bernstein, S.L., Int. J. Mass Spectrom., 2006,252, 180-188.

25. Beta-defensin evolution: selection complexity and clues for residues of functional importance. Semple, C. A. M.; Taylor, K.; Eastwood, H.; Barran, P. E.; Dorin, J. R., Biochemical Society Transactions 2006, 34, 257-262.

2005 | Back to top |

24. The formation of a complex between calmodulin and neuronal nitric oxide synthase is determined by ESI-MS.
Shirran, S., Garnaud, P., Daff, S., McMillan, D., and Barran, P., J R Soc Interface, 2005,2, 465-476.

23. Evolution of Constrained Gonadotropin-releasing Hormone Ligand Conformation and Receptor Selectivity.
Barran, P.E., Roeske, R.W., Pawson, A.J., Sellar, R., Bowers, M.T., Morgan, K., Lu, Z., Tsuda, M., and Millar, R.P., J.Biol. Chem.,2005,280, 38569-38575.

22. Conformation of glycosaminoglycans by ion mobility mass spectrometry and molecular modelling.
Jin, L., Barran, P.E., Deakin, J.A., Lyon, M., and Uhrin, D. , Phys. Chem. Chem. Phys. , 2005,7, 3464-3471.

21. The complexity of selection at the major primate beta-defensin locus.
Semple, C.A.M., Maxwell, A., Gautier, P., Kilanowski, F.M., Eastwood, H., Barran, P.E., and Dorin, J.R., BMC Evol Biol, 2005, 5, 1471-2148.

20 Gas-phase study of the chemistry and coordination of lead(II) in the presence of oxygen-, nitrogen-, sulfur-, and phosphorus-donating ligands.
Puskar, L., Barran, P.E., Duncombe, B.J., Chapman, D., and Stace, A.J., J. Phys. Chem. A, 2005,109, 273-282.

19. Structural investigation of naturally occurring peptides by electron capture dissociation and AMBER force field modelling.
Polfer, N. C.; Haselmann, K. F.; Langridge-Smith, P. R. R.; Barran, P. E., Molecular Physics, 2005, 103, 1481-1489.

18. Is it biologically relevant to measure the structures of small peptides in the gas-phase?
Barran, P. E.; Polfer, N. C.; Campopiano, D. J.; Clarke, D. J.; Langridge-Smith, P. R. R.; Langley, R. J.; Govan, J. R. W.; Maxwell, A.; Dorin, J. R.; Millar, R. P.; Bowers, M. T., Int. J. Mass Spectrom. 2005, 240, 273-284.

2004 and earlier | Back to top |

17. Covalently bound and non-covalently bound beta-defensin dimers: Establishing a link between tertiary structure and antimicrobial activity.
Clarke, D. J.; Langley, R. J.; Govan, J. R.; Dorin, J. R.; Barran, P. E.; Campopiano, D. J., Prot Sci., 2004, 13, 84-85.

16. Structure-activity relationships in defensin dimers – A novel link between beta-defensin tertiary structure and antimicrobial activity.
Campopiano, D.J., Clarke, D.J., Polfer, N.C., Barran, P.E., Langley, R.J., Govan, J.R.W., Maxwell, A., and Dorin, J.R. , J. Biol. Chem., 2004,279, 48671-48679.

15. Gonadotropin-releasing hormone-induced activation of diacylglycerol kinase-zeta and its association with active c-Src.
Davidson, L., Pawson, A.J., de Maturana, R.L., Freestone, S.H., Barran, P., Millar, R.P., and Maudsley, S., J. Biol. Chem, 2004,279, 11906-11916.

14. The effect of the initial water of hydration on the energetics, structures, and H/D exchange mechanism of a family of pentapeptides: An experimental and theoretical study.
Wyttenbach, T., Paizs, B., Barran, P., Breci, L., Liu, D.F., Suhai, S., Wysocki, V.H., and Bowers, M.T., J. Am. Chem. Soc., 2003,125, 13768-1377.

13. Mutation in a short-chain collagen gene, CTRP5, results in extracellular deposit formation in late-onset retinal degeneration: a genetic model for age-related macular degeneration.
Hayward, C., Shu, X.H., Lennon, A., Barran, P., Zareparsi, S., Sawyer, L., Hendry, G., Dhillon, B., Milam, A.H., Luthert, P.J., Swaroop, A., Hastie, N. D., Jacobson, S. G. and Wright, A. F., Hum. Mol. Genet., 2003,12, 2657-2667.

12. Sequential hydration of small protonated peptides.
Liu, D.F., Wyttenbach, T., Barran, P.E., and Bowers, M.T. , J. Am. Chem. Soc. , 2003,125, 8458-8464.

11. Stable Pb(ROH)(N) (2+) complexes in the gas phase: Softening the base to match the Lewis acid. Akibo-Betts, G., Barran, P.E., Puskar, L., Duncombe, B., Cox, H., and Stace, A.J. , J. Am. Chem. Soc., 2002,124, 9257-9264.

10. Comparisons in the behavior of stable copper(II), silver(II), and gold(II) complexes in the gas phase: Are there implications for condensed-phase chemistry?
Walker, N. R.; Wright, R. R.; Barran, P. E.; Murrell, J. N.; Stace, A. J., J. Am. Chem. Soc., 2001, 123, 4223-4227.

9. Unexpected stability of [Cu center dot Ar](2+), [Ag center dot Ar](2+), [Au center dot Ar](2+), and their larger clusters.
Walker, N. R.; Wright, R. R.; Barran, P. E.; Cox, H.; Stace, A. J., J. Chem. Phys., 2001, 114, 5562-5567.

8. A gas-phase study of the coordination of Mg2+ with oxygen- and nitrogen-containing ligands.
Walker, N.; Dobson, M. P.; Wright, R. R.; Barran, P. E.; Murrell, J. N.; Stace, A. J., J. Am. Chem. Soc., 2000, 122, 11138-11145.

7. The ultraviolet photofragmentation of doubly charged transition metal complexes in the gas phase: Initial results for [Cu.(pyridine)(n)](2+) and [Ag.(pyridine)(n)](2+) ions.
Puskar, L.; Barran, P. E.; Wright, R. R.; Kirkwood, D. A.; Stace, A. J., J. Chem. Phys., 2000, 112, 7751-7754.

6. Competitive charge transfer reactions in small [Mg(H2O)(N)](2+) clusters.
Barran, P. E.; Walker, N. R.; Stace, A. J., J. Chem. Phys., 2000, 112, 6173-6177.

5. Cluster-to-metal electron transfer in [Mn center dot (pyridine)(n)](2+) complexes. Akibo-Betts, G.; Barran, P. E.; Stace, A. J., Chem. Phys. Lett., 2000, 329, 431-436.

4. Stable gold(II) complexes in the gas phase.
Walker, N. R.; Wright, R. R.; Barran, P. E.; Stace, A. J., Organometallics 1999, 18, 3569-3571.

3. Gas phase multicollisional reactions of metal cluster cations with water molecules.
Mikhailov, V. A.; Barran, P. E.; Stace, A. J., Phys. Chem. Chem. Phys., 1999, 1, 3461-3465.

2. Reactions of mixed Pb-M(+)/methanol clusters.
Barran, P. E.; Mikhailov, V.; Stace, A. J., J. Phys. Chem. A, 1999, 103, 8792-8798.
1997

1. Stability of carbon clusters C-N for 46 <= N <= 102.
Barran, P. E.; Firth, S.; Stace, A. J.; Kroto, H. W.; Hansen, K.; Campbell, E. E. B., Int. J. Mass Spectrom., 1997, 167, 127-133.

Book Chapters | Back to top |

Ion Mobility Spectrometry – Mass Spectrometry: Theory and Applications edited by Charles Wilkins and Sarah Trimpin, Taylor and Francis 2010

Development of an Ion-Mobility-Capable Quadrupole Time-of- Flight Mass Spectrometer to Examine Protein Conformation in the Gas Phase
Bryan J. McCullough, Peter A. Faull, and Perdita E. Barran