Perdita Barran’s Research Group
We develop mass spectrometry based methods and instruments to allow us to look at conformation, conformational change and aggregation. Methods that allow us to preserve non-colvalent protein complexes are also applied to inorganic supramolecular biomimetic systems. We also generate IM-MS data from standard small molecules and proteins that can be used to calibrate TW IM-MS instrumentation.
Our principal areas of research interest are in understanding pre-fibrillar aggregation, intrinsically disordered proteins and how to tame disorder, probing the stability of protein complexes and of model peptide systems.
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