{"id":639,"date":"2019-07-08T09:09:59","date_gmt":"2019-07-08T09:09:59","guid":{"rendered":"https:\/\/www.mbc.manchester.ac.uk\/barrangroup\/?p=639"},"modified":"2019-07-08T10:03:47","modified_gmt":"2019-07-08T10:03:47","slug":"discovery-of-volatile-biomarkers-of-parkinsons-disease-from-sebum","status":"publish","type":"post","link":"https:\/\/www.mbc.manchester.ac.uk\/barrangroup\/2019\/07\/08\/discovery-of-volatile-biomarkers-of-parkinsons-disease-from-sebum\/","title":{"rendered":"Discovery of Volatile Biomarkers of Parkinson\u2019s Disease from Sebum"},"content":{"rendered":"

Parkinson\u2019s disease (PD) is a progressive, neurodegenerative disease that presents with significant motor symptoms, for which there is no diagnostic chemical\u00a0test. We have serendipitously identified a hyperosmic individual, a \u201cSuper Smeller\u201d who can detect PD by odor alone, and our early pilot studies have indicated that the odor was present in the sebum from the skin of PD subjects. Here, we have employed an unbiased approach to investigate the volatile metabolites of sebum samples obtained noninvasively from the upper back of 64 participants in total (21 controls and 43 PD subjects). Our results, validated by an independent cohort\u00a0(n<\/i>=31), identified a distinct volatiles-associated signature of PD, including altered levels of perillic aldehyde and eicosane, the smell of which was then described as being highly similar to the scent of PD by our \u201cSuper Smeller\u201d.<\/p>\n

\"\"<\/p>\n

Drupad K. Trivedi,\u2020 Eleanor Sinclair,\u2020 Yun Xu,\u2020,\u22a5 Depanjan Sarkar,\u2020 Caitlin Walton-Doyle,\u2020<\/em>
\nCamilla Liscio,\u2021 Phine Banks,\u2021 Joy Milne,\u2020 Monty Silverdale,\u00a7 Tilo Kunath,\u2225 Royston Goodacre,\u2020,\u22a5<\/em>
\nand Perdita Barran*,\u2020 <\/em><\/p>\n

\u2020 Manchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Princess Street, Manchester, U.K., M1 7DN<\/em>
\n\u2021 Anatune, 4 Wellbrook Way, Girton, Cambridge, U.K., CB3 0NA<\/em>
\n\u00a7 Department of Neurology, Salford Royal Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, U.K., M6 8HD<\/em>
\n\u2225 Institute for Stem Cell Research, School of Biological Sciences, The University of Edinburgh, Edinburgh, U.K., EH16 4UU<\/em>
\n\u22a5 Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Crown Street, Liverpool, U.K., L69 7ZB<\/em><\/p>\n

https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acscentsci.8b00879<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Parkinson\u2019s disease (PD) is a progressive, neurodegenerative disease that presents with significant motor symptoms, for which there is no diagnostic chemical\u00a0test. We have serendipitously identified a hyperosmic individual, a \u201cSuper Smeller\u201d who can detect PD by odor alone, and our early pilot studies have indicated that the odor was present in the sebum from the … <\/p>\n

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